Ok, my wife has been having allergy attacks for the past couple hours, her eyes were red, her nose was running, and she was NOT in the mood for me to take a picture! But I had to try ISO 1600 with my 50mm 1.4 wide open to see what it would look like. There was one dim lamp across the room with a flourescent bulb, so this need a bunch of color correcting, and some other help. But overall, ISO 1600 with a 50mm 1.4 wide open is quite impressive!