I like the idea here and the expression on the model is great. In my opinion, what brings it down for me is the dirty test tubes and reflections on model. Also, the test tube rack is tilted downward to the left.
I personally would have had the focus on the eyes of the girl and the glasses blurry but not the persone itself. The lighting is ok but is personally would have done a bit of curve working with it in photoshop
Her expression is a little too overexagerrated. I believe it does have to be dramatic enough to convey the "disgruntled" message, but it's too much. Color seems a little too yellow all over.
The white balance is perhaps a little of, and the ligthting a little to soft for my taste. For example this wall behind the girls is probably supposed to be white (?) but it's just a bit red and dull gray.
I like the gap between the glass things (don't know the english word for it), it draws the attention a bit more to her face.
I think the focus should have been set to her face rather than the glass things, or to have her even more out of focus would perhaps work also.