These eyes do not "say" despair to me...they look focused, interested, maybe like they are studying or something but they definitely do not look in despair. Maybe if you included something about why this individual is in despair it would help understand better.
very interesting photo... I believe that the eyes alone may not be quite enough to really convey your 'despair' in this shot. There is a sense of deep thought here, but maybe including some more of the face would better relay despair... nice work :) - setzler